On - the - main



UNITED STATES PATENT OFFICE.

ALFRED EINHORN, OF MUNICH, GERMANY, ASSIGNOR TO THE FARBWERKE,

VORMALS MEISTER, LUOIUS & BRIINING, OF HOOHST ON THE MAIN, I

GERMANY.

GLYCOCOLAMIDOCINNAMIC ACID ESIER AND PROCESS OF. MAKING SAME.

SPECIFICATION forming part of Letters Patent No. 625,159, dated May 16,1899.

Application filed March 7, 1899. Serial No. 708,080. (Specimens) To allwhom it may concern.-

Be it known that I, ALFRED EINHORN, Ph. D., professor of chemistry, acitizen of the Empire of Germany, residing at Munich, Ger- 5 many, haveinvented certain new and useful Improvements in the Manufacture of GlycocolamidocinnamicAcid Esters, of which the following is a specification.

A compound characterized by its anes- I thetic power and which may serveas a substitute for cocain is obtained by first combiningmeta-amidocinnamicacid ester with chloracetylchlorid and then the thusobtained chloracetylcinnamicacid ester with a1nins.' I 5 Thusglycocolamidocinuamicacid esters are formed having the constitution/OH:CH- ooo alkyl compound two hundred and fifty-three grains are heatedon the Water-bath for about two hours with one hundred and forty-sixgrams ficulty in Water.

of diethylamin and five hundred grams of alcohol, whereupon the alcoholis distilled off and soda solution added to the residue.

The new basic compound the diethylamidm acetyl -meta-amidocinnamicacidmiethylester separates out. It is an oil easily soluble in other,alcohol, benzene, and soluble with dif- From the ethereal solution ofthe compound the chlorhydrate of the ester is separated by addition ofalcoholic hydrochloric acid having the melting point 165 centigrade.

Having now described my invention, what I claim is- 1. The process forthe manufacture of .alkyl amidoacetyl-meta-amidocinnamicacid esters,which consists,in first combining meta-amidocinnamicacid ester withchloracetylclhlorid and then with amins, substantially as described.

2. As a new product, thediethylamidoacetyl-meta-amidocinnamicacid-methylester,being an oileasilysoluble in alcohol, ether, benzene, soluble with difficulty in water,forming with acids salts soluble in water, its chlorhydrate having themelting-point 165 centigrade. I a

In testimony that I claim the foregoing as my invention I have signed myname in presence of two subscribing witnesses. I

i ALFRED EINHORN.

Witnesses:

HALL PHILOMINA, EMIL HENZEL.

